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About the Viewer
Help map a neuron’s power grid
We’re building whole‑neuron, 3D maps of mitochondrial distribution and shape in hundreds of identified central‑nervous‑system neurons. Using serial‑block‑face electron microscopy, we image entire cell bodies and dendrites at nanometer resolution, then split the massive datasets into small, neuron‑centered tiles. Deep‑learning models make a first pass at segmenting nuclei, mitochondria, and neurons; citizen scientists quickly proofread and refine those overlays. We combine volunteers’ edits into accurate labels, then use them to build precise 3D models and take measurements.
What makes this possible
We use serial‑block‑face electron microscopy (SBF‑SEM) to capture entire neurons — not fragments — at ultrastructural resolution. That combination of fine detail and wide field of view lets us compare different parts of the same cell.
Why we need you
AI segments these huge images but still misplaces boundaries. Volunteers correct those errors; independent edits are pooled into consensus labels so research‑grade reconstructions can proceed.
What you’ll do
Open small image tiles, compare the raw EM slice to a colored overlay, use the paintbrush to edit objects, and save your edits. Each small contribution helps build accurate 3D reconstructions.
By mapping mitochondrial size, shape, and distribution across entire neurons (cell bodies, dendrites, and axon terminals), we aim to answer a clear question: how do nerve cells regulate the size, density, and placement of their power sources to meet local energy needs?
How do I register?
How do I use the Paintbrush tool?
Open the legend and click an object color to focus on that object and enable editing tools.
- Select Add to paint the object color, or Subtract to erase it.
- Adjust Brush size with the slider; a preview circle follows the cursor.
- Use Opacity to compare edits against the raw image, then click Save Edits.
Note: Use the Merge button to change a mitochondria's color to match another across all frames.
How do I approve a frame?
When a slice is ready, click Approve Frame below the viewer header to mark it approved.
Approved frames count toward the green progress indicator on the homepage.
How do I track progress?
The top progress bar shows each frame's status: grey = assigned, yellow = in progress, green = approved.
Click a bar segment to jump to that frame and review its thumbnail in the timeline strip.
Any tips?
- Assign a tile to yourself before editing so changes save to your overlay.
- Save often and work in short passes.
- Use the opacity slider to check edits against the base image.
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